The learner will understand the pharmacological mechanisms of opioids, including opioid dependence and its treatment with buprenorphine.
After completing this activity participants will be able to:
Identify the 3 types of opioid receptors (mu, kappa and delta) and their reaction to the presence of different types of opioids.
Differentiate between opioid agonists, partial agonists and antagonists.
Understand the distinction between neutral antagonists and reverse agonists.
Understand the relationship between buprenorphine's pharmacological make-up and its efficacy in treatment of opioid dependence.
Describe the causes of and relationship between opioid tolerance, dependence and withdrawal.