Medical students will recognize that most human disease is the result of complex interactions between genetics and environment and will be able to determine the relative contribution of these factors to define occurrence likelihoods and appropriate preventative measures.
After completing this activity participants will be able to:
Discuss the role of genetic predisposition and environmental factors in determining multifactorial conditions, and the models that attempt to explain these complex interactions.
Identify the factors that increase the likelihood of a defined genetic etiology (single-gene, chromosomal) when assessing a personal or family history of common conditions.
Determine appropriate recurrence risks for complex conditions using knowledge of multifactorial inheritance and published empiric risk data.
Assess the benefits and limitations of susceptibility gene tests for common conditions.
Effectively communicate the current (and often limited) knowledge base about the inheritance of complex conditions and the options for dealing with those risks to patients.